Refractory Fulminant Acute Disseminated Encephalomyelitis (ADEM) in an Adult

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Refractory Fulminant Acute Disseminated Encephalomyelitis (ADEM) in an Adult

Acute disseminated encephalomyelitis (ADEM) is characterized by its rapid progression with variable symptoms and severity in adults and children. Multiple therapeutic options have been proposed, but solid evidence is yet to be gathered. We describe an adult man with a fulminant form of ADEM unresponsive to numerous treatment modalities.

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Measles with acute disseminated encephalomyelitis (ADEM).

We report a seven year old male with measles associated acute disseminated encephalomyelitis (ADEM) despite having received measles vaccination in infancy. The diagnosis was based on serum antimeasles antibodies and MRI brain. The patient was managed with high dose corticosteroids along with supportive measures. There was a complete neurologically and physica recovery.

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Acute Disseminated Encephalomyelitis (ADEM) Presenting with Bilateral Optic Neuritis.

A 43-year old lady presented with progressive loss of vision in both eyes followed by rapid deterioration of consciousness within the next few days. This was preceded by a viral infection one week before her presentation. At presentation she had evidence of meningism and signs of bilateral upper motor neuron lesions and was managed initially as acute meningoencephalitis with antibiotics. The br...

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Cyclosporine in the Treatment of a Case of Fulminant and Refractory Acute Disseminated Encephalomyelitis

BACKGROUND Acute disseminated encephalomyelitis (ADEM) is a rare, monophasic, demyelinating disease of the CNS which sometimes could be refractory to traditional treatment. CASE PRESENTATION We present a case of fulminant ADEM which is treated with combination of corticosteroid, intravenous immunoglobulin and cyclosporine. CONCLUSION Immunosuppressive agents such as cyclosporine may be effe...

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Acute disseminated encephalomyelitis: an update.

Acute disseminated encephalomyelitis (ADEM) is a monophasic autoimmune demyelinating disease of the central nervous system that typically follows a febrile infection or a vaccination. Children are predominantly affected. A plethora of viral and bacterial pathogens and a number of vaccinations have been associated with ADEM. Experimental animal studies indicate that both primary and secondary au...

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ژورنال

عنوان ژورنال: Frontiers in Neurology

سال: 2014

ISSN: 1664-2295

DOI: 10.3389/fneur.2014.00270